Genetic prodrug activation in erbB-2 overexpressing breast cancer
نویسندگان
چکیده
منابع مشابه
Testing for erbB-2 by immunohistochemistry in breast cancer.
The success of recent clinical trials using Herceptin (trastuzumab, a humanized anti–erbB-2 antibody) as therapy for patients with advanced breast cancer 1-3 has generated a great deal of renewed interest in laboratory testing for overex-pression of the erbB-2 oncoprotein. An article by Jacobs et al 4 in this issue of the Journal describes an interesting study evaluating interlaboratory agreeme...
متن کاملMolecular markers (c-erbB-2, p53) in breast cancer.
The aim of our study was to evaluate the correlation between clinical characteristics, histopatologic features and c-erbB-2 as well as p53 expression in cancer tissues. Breast cancer tissue was obtained from 184 female subjects with primary breast cancer. According to hormonal status patients were divided into two groups - 64 belonged to the premenopausal group and 120 to postmenopausal group. ...
متن کاملSerum c-erbB-2 protein in breast cancer patients.
Measurements of c-erbB-2 protein were done in sera of 20 normal women, 22 benign breast disease patients and in respectively 43 and 51 samples from primary breast cancer patients obtained prior to and after surgical interventions. Mean value of serum c-erbB-2 in non-malignant women was insignificantly different from the value in the breast cancer group. Positivity rate of serum c-erbB-2 in the ...
متن کاملBuformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice
BACKGROUND Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar properties. Although buformin was shown to reduce mammary tumor burden in carcinogen models, the anti-cancer effects of buformin on different breast cancer subtypes and the underl...
متن کاملCorrelation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer
Correlation between serum and un-stimulated whole saliva c-erbB-2 concentrations in women with breast cancer Dr. Agha-Hosseini F.,1 Dr. Mirzai-Dizgah E.,2 Dr. Rahimi A.3 1Professor, Department of Oral Medicine. Dental Research Center, School of Dentistry, Medical Sciences / University of Tehran, Tehran, Iran. 2Assistant professor, Department of Physiology, School of Medicine, Army University ...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 1999
ISSN: 1465-542X
DOI: 10.1186/bcr-1999-66591